The immune system is normally stimulated by medicinal mushrooms through innate immunity, which is primarily mediated by phagocytic cells. These cells consume invasive pathogens or interact with pathogen components, which is either instance promotes the release of cytokines and chemokines, which in turn further activates innate and adaptive immunity. By identifying conserved chemical patterns in the microorganisms, pattern-recognition receptors (PRR) on the cell surface, such as Toll-like receptors (TLR), mannose receptors, and dectin-1, start the response. The use of immunomodulating compounds derived from this mushrooms has grown in popularity. For instance, lentinan has been used extensively in Japan to treat cancer patients. Medical Mushrooms.






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